Safety and tolerability of regadenoson CMR

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Safety and tolerability of regadenoson CMR

AIMS Knowledge of adverse events associated with regadenoson perfusion cardiac magnetic resonance (CMR) and patient tolerability has implications for patient safety and staff training. We sought to assess the safety and tolerability of regadenoson stress CMR. MATERIALS AND METHODS A group of 728 consecutive patients (median age 58, 44% female) and 25 normal volunteers (median age 21, 24% fema...

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Safety and tolerability of intravenous regadenoson in healthy subjects: A randomized, repeat-dose, placebo-controlled study

BACKGROUND Regadenoson is a selective A2A adenosine receptor agonist indicated for radionuclide myocardial perfusion imaging in patients unable to undergo adequate exercise stress. However, the safety, tolerability, and plasma concentrations associated with repeated doses have not previously been assessed. METHOD AND RESULTS Healthy males and females were randomized to receive intravenous reg...

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LV wall motion assessment during regadenoson vasodilator stress CMR

Background Regadenoson (REG) is a commonly used vasodilator stress agent that causes an increase in sympathetic response with associated increase in myocardial contractility and ventricular function in addition to coronary vasodilation. This agent has demonstrated high accuracy to detect coronary stenosis during myocardial perfusion imaging, but global and regional LV functional changes immedia...

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Safety, tolerability and feasibility of adenosine stress CMR in high-risk patients

Background Adenosine stress cardiovascular magnetic resonance (CMR) provides effective cardiac prognostication in patients with suspected coronary artery disease. However its use has been limited in high-risk patients and some reservations exist about offering adenosine stress CMR in patients with significant aortic stenosis, asthma, severe left ventricular (LV) systolic dysfunction, significan...

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The safety and tolerability of regadenoson in patients with end-stage renal disease: the first prospective evaluation.

BACKGROUND There has not been any prospective evaluation of the safety and tolerability of regadenoson (REG)-stress in patients with end-stage renal disease (ESRD). METHODS From the pooled database of two identically designed randomized, double-blinded, placebo-controlled clinical trials, ASSUAGE and ASSUAGE-CKD (IV-aminophylline vs placebo following REG-stress), we extracted the placebo-trea...

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ژورنال

عنوان ژورنال: European Heart Journal - Cardiovascular Imaging

سال: 2014

ISSN: 2047-2404,2047-2412

DOI: 10.1093/ehjci/jet278